International Journal of Malaria Research and Reviews
Volume 4 Issue 2 Page 19 - 28. April 2016

Copyright 2015 Discourse Journals


Full Length Research Paper

Emetine dihydrochloride hydrate showed potent antimalarial properties on the multidrug resistant strain (K1) of
Plasmodium falciparum: A step forward towards drug repurposing

Abdullahi M. Daskum1, Rizwan A. Ansari1 and Abba Umar2

1Department of Biological Sciences, Yobe State University, P.M.B 1144, Damaturu.
2Department of Biological Sciences, University of Maiduguri, P.M.B 1069, Maiduguri, Borno State

Abstract

Malaria is a life threatening infectious disease that is characterized by recurrent high fevers and, neurological impairments such as brain damage and coma, in the case of cerebral malaria. Pregnant women and children are most at risk with 85% of deaths occurring in children under five years of age. Due to lack of a licensed malaria vaccine and resistance to available antimalarials including the frontline artemisinin combination therapies (ACTs), malaria imposes a heavy social burden that has delayed economic development in regions where it is endemic. Traditional drug discovery process is both cost and time consuming. Drug repositioning or the re-profiling of existing drugs for diseases other than those they were originally meant for, offers the opportunity to explore the existing knowledge on drugs, diseases and targets and helps us to find a new use of already available compound or drug. In addition, drug repurposing shortens the traditional drug discovery pipeline. SYBR Green flow cytometer method and microscopy were used to determine the  in vitro antimalarial effect of the anti-protozoal drug emetine dihydrochloride hydrate namely on the multidrug resistant strain (K1) of  Plasmodium falciparum. Emetine showed potent antimalarial activity on the multidrug resistant strain (K1) of  P. falciparum, with about 50% parasite clearance between 12.5 and 25 nM, and an estimated 90% parasite clearance at 50 nM.The finding validates previous results of other research and contributes additional evidence suggesting the potent antimalarial effect of emetine on the K1 strain of P. falciparum. 

Keywords: Malaria, Emetine dihydrochloride hydrate, SYBR green flow cytometry, Microscopy

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