International Journal of Malaria Research and Reviews
December 2020 Vol. 8(1), pp. 1-12

Copyright 2020 Discourse Journals


Full Length Research Paper

Adverse Effects of Anti-malarial Drugs Used in the Treatment of Malaria Cases Caused by Species Other than Plasmodium falciparum: A scoping Review

Philippe Mulenga-Cilundika1 2, Joël Ekofo2, Dieudonné Bagalwa2, Mada Ibaji2 , Faustin Chenge 1 2

1University of Lubumbashi, Faculty of Medicine and school of public health, Lubumbashi, DRC
2Centre de Connaissance en Santé en République Démocratique du Congo, Kinshasa, DRC.

Abstract

Antimalarial drugs used in the treatment of malaria caused by species other than Plasmodium falciparum also have adverse effects. The objective of this review is to identify the different molecules used in the treatment of these forms of malaria and the adverse effects they cause in humans. We conducted a scoping review by searching PubMed and Google Scholar data bases as well as gray literature documents. Data were selected, collected and characterized by four reviewers using the methodological guidelines described by Arksey and O'Malley in 2005 and by Levac, Colquhoun and O'Brien in 2010.A total of 37 documents were reviewed. Drugs such as chloroquine and proguanil very rarely have serious adverse effects at recommended doses. Unfortunately, in some parts of the world, these products are no longer effective prophylactic agents. Potentially fatal reactions are caused by the use of pyrimethamine-sulfadoxine and amodiaquine, so these molecules are no longer recommended for prophylaxis. Mefloquine, despite its effects on the central nervous system, is indicated for chemoprophylaxis of malaria caused by all species. The artemether-lumefantrine combination often produces effects that are difficult to distinguish from malaria symptoms, but the most important adverse effect is hemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Cinchonism is a common side effect observed after the intake of therapeutic doses of quinine.Regardless ofthe plasmodial species involved, the molecules that can be used in the treatment of malaria are quite similar. However, their side effects can vary from one species to another.

Keywords: Effects, Antimalarial Drugs, Treatment of Malaria, Plasmodium Vivax, Plasmodium Ovale, Plasmodium Malariae, Plasmodium Knowlesi.

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