Journal of Microbiology Research and Reviews
Volume 5 Issue 1 Page 1-5. March 2018
Copyright 2018 Discourse Journals


Helicobacter pylori and asthma are they linked in Côte d'Ivoire?

Koffi KS1,4, Meite S2, Boni-Cisse C2, N’guessan C3, Coulibaly KJ1, Ouattara A1, Kacou-N’douba A1,4, Dosso M1 and Dassé SR3

1Institut Pasteur de Côte d’Ivoire. 2Laboratoire d’Immunologie Centre Hospitalo-Universitaire de Cocody. 3Laboratoire de Bactériologie Virologie Centre Hospitalo-Universitaire de Yopougon. 4Laboratoire de Bactériologie Virologie Centre Hospitalo-Universitaire de Cocody


Abstract

Helicobacter pylori (H. pylori) causes gastric diseases and extra digestive diseases, such as lung disease. As a result of its lipo polysaccharide nature, H. pylori is able to guide the immune response towards Th1 or Th2 (Lymphocyte T helper 1 or 2) profiles by stimulating toll-like receptors (TLR) of the dendritic cells of the respiratory mucosa hence controlling asthmatic occurrence. This study aims to find a correlation between anti-H. pylori antibodies and asthma evolution. A cross-sectional study was carried out from January 2008 to June 2009 on asthmatic subjects (cases) and non asthmatic blood donors (controls). Anti-H. Pylori’s antibodies was detected in all subjects using HP® test kit (Acon laboratories). In asthmatics, expiratory volume were also measure by spirometry. The odds ratio (OR) and relative risk (RR) were used to compare cases and controls groups. p<0.05 was considered significant. Anti-H. Pylori antibodies prevalence was lower in the case groups (47.1%) compared to control groups (60.3%). H. pylori is not linked to the risk of asthma occurrence.

Keywords: Asthma, H. pylori, antibodies.


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